Mounjaro (tirzepatide) lowered weight more than Ozempic (semaglutide) in SURPASS-2, a head-to-head trial against Ozempic's top dose, 1 mg: an estimated 1.9 to 5.5 kg more over 40 weeks, in 1,879 adults with type 2 diabetes (Frías 2021). Individual results vary and are not guaranteed. At GetLean in Singapore, Mounjaro is from S$488 a month, all-in, if Dr Quek prescribes it after a video consultation.
Ozempic and Mounjaro are different medicines. Ozempic is semaglutide, registered in Singapore for type 2 diabetes only, and GetLean does not prescribe it (NDF). Ozempic's medicine is prescribed as Wegovy, which is registered here for weight management (NDF), and it is also from S$488 a month. At Wegovy's doses, the head-to-head trial SURMOUNT-5 found a mean weight change of −20.2% with tirzepatide against −13.7% with semaglutide over 72 weeks (Aronne 2025). The first step is a 30-minute video consultation with Dr Quek for S$20, refunded in full if he decides medication is not right for you.
Availability in Singapore. Mounjaro is registered with Singapore's Health Sciences Authority, and its registered indication includes weight management. Ozempic is registered with Singapore's Health Sciences Authority for type 2 diabetes only. It has no registered weight-management indication here, so prescribing it for weight is off-label, and GetLean does not prescribe it. Which medicine suits a particular person, if any does, is decided by the doctor who assesses them.
Is Mounjaro better than Ozempic for weight loss?
In both head-to-head trials below, tirzepatide, the medicine in Mounjaro, lowered weight more than semaglutide, the medicine in Ozempic and Wegovy, at every dose compared. The trials ran in different people and at different semaglutide doses, so each answers a different version of the question:
| Trial | Who took part | Doses compared, once weekly | Weight result |
|---|---|---|---|
| SURPASS-2, 40 weeks | 1,879 adults with type 2 diabetes | tirzepatide 5, 10 or 15 mg against semaglutide 1 mg, Ozempic's top dose | an estimated 1.9 kg, 3.6 kg and 5.5 kg more lost with tirzepatide (Frías 2021) |
| SURMOUNT-5, 72 weeks | 751 adults with obesity and without type 2 diabetes | tirzepatide 10 or 15 mg against semaglutide 1.7 or 2.4 mg, Wegovy's doses | −20.2% against −13.7% (Aronne 2025) |
Both trials were open-label: participants and investigators knew which medicine was which. SURPASS-2 reports its weight result as the difference between the arms, and SURMOUNT-5 also found a larger fall in waist size, −18.4 cm against −13.0 cm. These are trial averages; individual results vary and are not guaranteed. Wegovy vs Mounjaro sets out SURMOUNT-5 in full, and why separate trials of each medicine cannot be lined up against each other.
Which medicine suits a particular person is Dr Quek's decision at the consultation, and it turns on their history, their other medicines and what they tolerate, not on a trial average.
Is Mounjaro the same as Ozempic?
No: Mounjaro is tirzepatide, made by Eli Lilly, and Ozempic is semaglutide, made by Novo Nordisk, two different medicines that are both given as a once-weekly injection (HSA register). Semaglutide acts at one hormone receptor, GLP-1, and tirzepatide at two, GIP and GLP-1 (Frías 2021).
| Mounjaro | Ozempic | |
|---|---|---|
| Medicine | tirzepatide | semaglutide |
| How it is taken | once-weekly injection | once-weekly injection |
| Registered in Singapore for | type 2 diabetes and, on its current registrations, weight management | type 2 diabetes only |
| Doses on the Singapore label | starts at 2.5 mg; maintenance dose 5 mg, 10 mg or 15 mg | starts at 0.25 mg; then 0.5 mg, and 1 mg if needed; nothing above 1 mg |
| At GetLean | prescribed when Dr Quek finds it clinically appropriate | not prescribed; its medicine is prescribed as Wegovy |
The registrations are in Singapore's product information for each (NDF; NDF). The medicine that shares Ozempic's molecule is Wegovy, and Wegovy vs Ozempic explains how those two differ.
How much do Mounjaro and Ozempic cost in Singapore?
At GetLean, Mounjaro is S$488 a month at 2.5 mg and 5 mg, S$788 a month at 7.5 mg and 10 mg, and S$1,088 a month at 15 mg (max dose), all-in. GetLean does not prescribe Ozempic, so it has no Ozempic price of its own: Ozempic's medicine is prescribed as Wegovy, at S$488 a month at 0.25 mg, 0.5 mg and 1 mg, the doses Ozempic comes in, S$788 a month at 1.7 mg and 2.4 mg, and S$1,088 a month at 7.2 mg (max dose).
| GetLean, per month, all-in | Mounjaro (tirzepatide), once weekly | Semaglutide, prescribed as Wegovy, once weekly |
|---|---|---|
| S$488 | 2.5 mg or 5 mg | 0.25 mg, 0.5 mg or 1 mg, the doses Ozempic comes in |
| S$788 | 7.5 mg or 10 mg | 1.7 mg or 2.4 mg |
| S$1,088 (max dose) | 15 mg | 7.2 mg |
The first video consultation with Dr Quek (30 minutes) is S$20, refunded in full if he decides medication is not right for you. After the taper, daily coaching and a monthly review with no medication is S$88 a month, if you wish.
What the monthly price covers:
- Doctor video consultation and ongoing medical oversight by Dr Quek
- The medication, as prescribed, delivered discreetly to you
- A personalised nutrition and daily activity plan
- Daily WhatsApp coaching, and your care team on WhatsApp from 9am to 9pm every day, Singapore time. Outside those hours an urgent symptom does not wait for a reply: go to an emergency department, or call 995 if it is an emergency.
- Dose reviews that work toward your lowest effective dose
The price is set by the dose, so it can change at a monthly review. Which medicine and dose suit you, if any, is Dr Quek's decision at your consultation, and a consultation does not guarantee a prescription. The pricing page sets out the whole programme, and Mounjaro in Singapore and Wegovy in Singapore have a page each.
Book your consult with Dr Quek.
Which is safer, Ozempic or Mounjaro?
The head-to-head trials found the same kind of side effects with both, mostly mild to moderate stomach and gut effects. In SURPASS-2, nausea was reported by 17 to 22% on tirzepatide and 18% on semaglutide 1 mg, diarrhoea by 13 to 16% and 12%, and vomiting by 6 to 10% and 8%; serious adverse events were reported in 5 to 7% and 3% (Frías 2021). In SURMOUNT-5, at Wegovy's doses, gastrointestinal effects were the commonest in both groups, mostly mild to moderate and mostly while the dose was being raised (Aronne 2025).
The Singapore product information for both lists one contraindication: hypersensitivity to the medicine or to any of its other ingredients (NDF). Whether either suits a person, given their history and their other medicines, is the assessing doctor's decision, and who should not take GLP-1 medication covers the cautions.
How are Mounjaro and Ozempic dosed?
Both are started at a low dose once a week and stepped up. On Singapore's label, Ozempic's first dose is 0.25 mg once weekly for four weeks, then 0.5 mg, and 1 mg after at least four weeks on 0.5 mg if needed; 0.25 mg is not a maintenance dose, and doses above 1 mg a week are not recommended (NDF). Mounjaro starts at 2.5 mg once weekly for four weeks, then 5 mg, with any further increases in 2.5 mg steps at least four weeks apart, to a maintenance dose of 5 mg, 10 mg or 15 mg (Singapore NDF).
Never change a prescribed dose on your own. How GLP-1 doses are stepped up covers both schedules.
What happens when Mounjaro or Ozempic is stopped?
In the trials that stopped each medicine outright, weight came back. In SURMOUNT-4, adults switched to placebo after 36 weeks on tirzepatide regained 14.0% of body weight over the following year (Aronne 2024). In the STEP 1 extension, adults who stopped semaglutide 2.4 mg, when the trial's lifestyle support also ended, regained about two-thirds of the weight they had lost within a year (Wilding 2022).
At GetLean, the programme is designed to end, and our philosophy is that the medication is the catalyst and what you keep is the result. The plan for coming off is the GetLean GLP-1 Taper Plan: Dr Quek steps the dose down at monthly reviews towards your lowest effective dose and, where clinically appropriate, off the medication, while daily WhatsApp coaching builds the habits that hold the result. Individual results vary. Never stop or change a prescribed medicine on your own.
If Ozempic was prescribed for type 2 diabetes, any decision to stop, reduce or switch it belongs to the doctor managing the diabetes. GetLean is a weight-management programme and does not replace that doctor.
Common questions
Is Mounjaro better than Ozempic for weight loss?
In the trials that compared them directly, tirzepatide, the medicine in Mounjaro, lowered weight more. Against Ozempic's top dose, semaglutide 1 mg, it gave an estimated 1.9 to 5.5 kg more weight loss over 40 weeks in adults with type 2 diabetes (Frías 2021); against semaglutide at Wegovy's doses, the mean change was −20.2% against −13.7% over 72 weeks (Aronne 2025). Both trials were open-label. Individual results vary and are not guaranteed.
Is Mounjaro the same as Ozempic?
No. Mounjaro is tirzepatide, which acts at two hormone receptors, GIP and GLP-1, and Ozempic is semaglutide, which acts at one, GLP-1 (Frías 2021). In Singapore, Ozempic is registered for type 2 diabetes only, while Mounjaro's current registrations cover type 2 diabetes and weight management (NDF; NDF). Wegovy is also semaglutide, the same medicine as Ozempic at Ozempic's doses, 0.25 mg, 0.5 mg and 1 mg.
Which is safer, Ozempic or Mounjaro?
A head-to-head trial found the same kind of side effects with both, mostly mild to moderate stomach and gut effects at similar rates: in SURPASS-2, nausea in 17 to 22% on tirzepatide and 18% on semaglutide 1 mg, diarrhoea in 13 to 16% and 12%, and vomiting in 6 to 10% and 8%. Serious adverse events were reported in 5 to 7% and 3% (Frías 2021). Whether either suits a person, given their history and their other medicines, is the assessing doctor's decision.
What's cheaper, Mounjaro or Ozempic?
At GetLean, Ozempic's medicine is prescribed as Wegovy, and it costs the same as Mounjaro. Mounjaro is S$488 a month at 2.5 mg and 5 mg, S$788 a month at 7.5 mg and 10 mg, and S$1,088 a month at 15 mg (max dose). Wegovy is S$488 a month at 0.25 mg, 0.5 mg and 1 mg, the doses Ozempic comes in, S$788 a month at 1.7 mg and 2.4 mg, and S$1,088 a month at 7.2 mg (max dose). Both prices are all-in. GetLean does not prescribe Ozempic, so it has no Ozempic price of its own.
Which medicine is better for diabetes, Ozempic or Mounjaro?
In SURPASS-2, tirzepatide lowered HbA1c, the long-term blood sugar measure, more than semaglutide 1 mg: by 2.01 to 2.30 percentage points against 1.86 over 40 weeks, in 1,879 adults with type 2 diabetes (Frías 2021). Individual results vary. Diabetes treatment is decided by the doctor managing the diabetes. GetLean is a weight-management programme and does not replace that doctor.
How do semaglutide and tirzepatide work?
Semaglutide acts at one hormone receptor, GLP-1, and tirzepatide at two, GIP and GLP-1 (Frías 2021). GIP and GLP-1 are gut hormones released when you eat, and both feed into the systems governing appetite and blood sugar. Acting at two receptors rather than one is the design difference between the medicines.
Does GetLean prescribe Ozempic?
No. At GetLean, Ozempic's medicine is prescribed as Wegovy, which is registered in Singapore for weight management (NDF), and Dr Quek also prescribes Mounjaro, when he finds one clinically appropriate after a video consultation. A consultation does not guarantee a prescription.
Who should not take Mounjaro or Ozempic?
Anyone hypersensitive to the medicine or to any of its other ingredients: that is the one contraindication in the Singapore product information for both (NDF). Whether either suits a person, given their history and their other medicines, is the assessing doctor's decision.
What happens when Mounjaro or Ozempic is stopped?
In the trials that stopped each medicine outright, weight came back: adults switched to placebo after 36 weeks on tirzepatide regained 14.0% of body weight over the next year (Aronne 2024), and adults who stopped semaglutide 2.4 mg regained about two-thirds of the weight they had lost within a year (Wilding 2022). At GetLean the plan for coming off is the GetLean GLP-1 Taper Plan: Dr Quek steps the dose down at monthly reviews towards the lowest effective dose and, where clinically appropriate, off the medication. Individual results vary. Never stop or change a prescribed medicine on your own.